He told the Daily Telegraph there could be changes to the health bill "if they help us improve care for patients".
But Mr Lansley warned the NHS would face "financial crisis within a matter of years" unless it was reformed.
Labour, as well as Lib Dem leader Nick Clegg, have called for the bill to be sent back to MPs for reconsideration.
'Threaten values'With the government's "listening exercise" on its proposed changes drawing to a close, Mr Lansley said: "We have always been clear that we are ready to accept any changes - substantial and significant - if they help us improve care for patients.
"When the Health and Social Care Bill comes back to Parliament, people should have every confidence that we will make the changes necessary to ensure the NHS is protected for our future generations.
"We will never privatise our NHS.
"But if we choose to ignore the pressures on it, the health service will face a financial crisis within a matter of years that will threaten the very values we hold so dear - of a comprehensive health service, available to all, free at the point of use and based on need and not the ability to pay.
Continue reading the main story“Start QuoteOur health service is facing huge challenges that, if not dealt with today, will almost certainly mean a crisis tomorrow”End QuoteAndrew LansleyHealth Secretary "I will not allow that to happen."Mr Lansley said reform was necessary in the face of "enormous financial pressures" caused by an ageing population and the rising cost of treatment.
He said the number of people in the UK aged above 85 had almost trebled over the past 25 years and was set to double again over the next 20 years. By 2034, one in 20 of the population would be aged over 85.
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